Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

Contact

5-Lipoxygenase: mechanisms of regulation.

Abstract

5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged. Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.

Authors: R├ądmark O, Samuelsson B.
Journal: J Lipid Res. 50 Suppl:S40-5
Year: 2009
PubMed: Find in PubMed