Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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CD16(+) monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells

Abstract

The CD16(+) subset of monocytes is dramatically expanded in peripheral blood during progression to AIDS, but its contribution to HIV pathogenesis is unknown. Here, we demonstrate that CD16(+) but not CD16(-) monocytes promote high levels of HIV replication upon differentiation into macrophages and interaction with T cells. Conjugates formed between CD16(+) monocyte-derived macrophages and T cells are major sites of viral replication. Furthermore, similar monocyte-T cell conjugates detected in peripheral blood of HIV-infected patients harbor HIV DNA. Thus, expansion of CD16(+) monocytes during HIV infection and their subsequent recruitment into tissues such as lymph nodes, brain, and intestine may contribute to HIV dissemination and establishment of productive infection in T cells.

Authors: Ancuta P, Kunstman KJ, Autissier P, Zaman T, Stone D, Wolinsky SM, Gabuzda D
Journal: Virology, 344(2):267-276
Year: 2006
PubMed: Find in PubMed