Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Endothelial colony-forming cells and inflammatory monocytes in HIV.

Abstract

The relationships between HIV infection, monocyte activation, and endothelial colony-forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14 CD16), and nonclassical monocytes (CD14 CD16) levels in HIV-infected participants virologically suppressed on antiretroviral therapy, HIV-infected treatment-naive participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected virologically suppressed group compared with the uninfected controls. CD14 CD16 percentages (but not CD14 CD16 cells) were significantly higher in both HIV-infected groups vs. uninfected controls. In the HIV-infected groups, ECFCs and CD14 CD16 intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.

Authors: Hays TR, Mund JA, Liu Z, Case J, Ingram DA, Gupta SK.
Journal: J Acquir Immune Defic Syndr.;68:550-3
Year: 2015
PubMed: Find in PubMed