Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Flow cytometry based monocyte subset analysis accurately distinguishes chronic myelomonocytic leukemia from myeloproliferative neoplasms with associated monocytosis.

Abstract

Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap syndrome characterized by peripheral blood monocytosis (absolute monocyte count/AMC ⩾ 1 × 10(9)/l, ⩾ 10% of the total white blood cell count) and an inherent risk for leukemic transformation.1,2 Monocytosis, however, is not pathognomic for CMML and can be associated with reactive and clonal processes, including MPN such as polycythemia Vera (PV) and primary myelofibrosis (PMF).

Authors: Patnaik MM, Timm MM, Vallapureddy R, Lasho TL, Ketterling RP, Gangat N, Shi M, Tefferi A, Solary E, Reichard KK, Jevremovic D.
Journal: Blood Cancer J. 2017 Jul 21;7(7):e584
Year: 2017
PubMed: Find in PubMed