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5-lipoxygenase: mechanisms of regulation.

Abstract

5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LT antagonists are used in treatment of asthma, more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged. Thus, understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.

Authors: R├ądmark O, Samuelsson B.
Journal: J Lipid Res. 50 Suppl:S40-5
Year: 2009
PubMed: Find in PubMed